Doxazo was founded in 2005 as a one-week sports camp called Wynnewood. The purpose of Wynnewood was to teach boys Godly character and build discipleship relationships with them through sports and Biblical teaching. In 2012, Doxazo expanded to reach both young men and women when they were invited to take their camp ministry to the Hi-Crest neighborhood in Topeka, KS. Doxazo joined the Topeka Rescue Mission in 2014 to further develop its model, ministry, and mission and receive support in that process. By 2016, Doxazo had expanded to include summer-long programming in Hi-Crest, Wynnewood, Fuchsia (the girls' counterpart to Wynnewood), the Doxazo Summer Intensive (DSI), and bi-annual, local service experiences in the Hi-Crest community.
In 2017, Doxazo transitioned ownership of its Hi-Crest programming to Fellowship Hi-Crest, a church in the community, and began focusing its attention on fully developing its discipleship programs. In 2018, Doxazo launched the Doxazo Discipleship Institute (DDI), a nine-month discipleship ministry for juniors and seniors in high school, and Awaken, a three-day conference-like experience for freshman in high school through seniors in college to gain a deeper understanding of what it means to live radically for the Kingdom of God in the present generation. Currently, Doxazo operates six programs: DSI, DDI, Awaken, Immersion, Wynnewood, and Fuchsia.